This Topical PFA seeks to fund patient-centered comparative clinical effectiveness research (CER) projects that focus on interventions that improve patient-centered outcomes in children and youth. PCORI is particularly interested in applications focusing on the following Special Areas of Emphasis (SAEs): prevention and treatment of obesity, addressing social determinants of health and social needs to improve health outcomes, and targeted prevention of substance misuse through identified risk factors. However, applications are not limited to these areas.