The National Institute of Mental Health (NIMH) seeks to advance its mission through the continuation of the NIH Research Education Program to support research education activities that complement and/or enhance the training of a workforce to meet the nation’s biomedical, behavioral and clinical research needs. Specifically, this NOFO will support innovative educational activities with a primary focus on national or regional mentoring networks that enhance professional development and foster career trajectories towards independent mental health research. All proposed networks should provide significant new opportunities, and should comprise efforts substantially beyond any ongoing mentoring, networking, or research education within academic programs, institutions, or pre-existing networks; or educational collaborations among institutions. Applications are not being solicited at this time. This notice is being issued to provide potential applicants ample time to develop strong, responsive applications. Investigators with expertise and insights in mentoring networks within research education activities that contribute to the development of a skilled cadre of investigators are encouraged to consider applying to the NOFO.