The Patient-Centered Outcomes Research Institute (PCORI) intends to release a Phased Large Awards for Comparative Effectiveness Research (PLACER) PCORI Funding Announcement (PFA) on Dec. 2, 2025, with the goal of funding high-quality patient-centered comparative clinical effectiveness research (CER) projects. This preannouncement provides potential applicants additional time to identify collaborators; obtain patient, community and partner input on potential studies; and create responsive, high-quality proposals.